LYCOS RETRIEVER
Lamivudine: Treatment
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Lamivudine does not cure AIDS or completely kill the HIV virus, but helps to prevent further damage by slowing down the production of new viruses. Treatment with lamivudine does not reduce the risk of passing infection on to others. You will still be able to pass HIV by sexual contact, by blood transfer or by sharing needles. You should always use appropriate precautions to prevent passing HIV on to others.
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Comment: Lamivudine clearly shows promise as a treatment for chronic hepatitis B. However, the optimal duration of therapy is unclear, and HBV DNA frequently reappears after the drug is stopped. Moreover, the ultimate impact on morbidity and mortality remains to be seen.
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Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves the seroconversion of e-antigen positive hepatitis B and ... improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.
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Lamivudine is used in the treatment of AIDS, usually in combination with AZT and/or other drugs. Although these drugs will not lead to a cure of this deadly malady, they do help slow down the destruction of the immune system by the AIDS virus. The drug is marketed in the United States under the trade name Epivir and in Canada under the trade name 3TC. Side effects include abdominal pain, nausea, tingling, burning, and numbness.
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Lamivudine is ... approved for the treatment of hepatitis B (Epivir HBV). Studies have shown that lamivudine can reduce the amount of hepatitis B virus to very low levels, although this effect does not always last. The treatment of Hepatitis B will likely require using combination therapy.
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