LYCOS RETRIEVER 
Lamivudine: Effects
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Lamivudine may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Lamivudine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
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Lamivudine exerts a virustatic effect against retroviruses by acting as a reverse transcriptase inhibitor. Lamivudine is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP... known as 3TC-TP), which inhibits HIV reverse transcription and HBV polymerase activity via viral DNA chain termination.[14] The principal mode of action of L-TP is inhibition of HIV reverse transcription via viral DNA chain termination after incorporation of the nucleoside analogue. L-TP is a weak inhibitor of mitochondrial DNA polymerase and mammalian DNA polymerases alpha and beta.[15] 3TC-LP is a structural analogue of deoxycytidine triphosphate (dC-TP), the natural substrate for reverse transcriptase. 3TC-TP appears to compete with naturally occurring dC-TP for incorporation into viral DNA by reverse transcriptase. Following incorporation of 3TC-TP into the viral DNA chain instead of dC-TP, viral DNA synthesis is terminated prematurely because the absence of a 3'-hydroxyl group on the oxathiolane ring prevents further 5' to 3' phosphodiester linkages. Lamivudine has in vitro virustatic activity against HIV-1, HIV-2, and HBV, but it appears to be inactive against other common human viruses (e.g., cytomegalovirus, Epstein-Barr virus, influenza virus, herpes simplex virus types 1 and 2, respiratory syncytial virus, varicella-zoster virus).[16]
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Lab tests, including liver and kidney function tests, may be performed while you use Lamivudine . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
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