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Kawasaki Disease: Child
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Once the diagnosis of Kawasaki disease is reasonably certain, IVIG 2 g/kg should be infused over a 10 to 12 hour period. It is often appropriate to observe children for 1 to 2 days early in the course while trying to ascertain the diagnosis of Kawasaki disease. A trial of antistaphylococcal antibiotics is warranted in cases where bacterial infection is a concern. When IVIG is given within the first 10 days of illness, the frequency of coronary artery aneurysms is reduced from about 25% to 3%. Although efficacy is less, IVIG administration may provide some benefit even after the 10th day. [19,20] About 90% of children will have resolution of fever and other signs within 24-48 hours after the IVIG infusion is begun.
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Kawasaki disease causes skin to peel on the hands and feet The main goals of treatment for Kawasaki disease are to reduce or prevent heart disease and to relieve the symptoms. Intravenous gamma globulin and aspirin are given to reduce the risk of heart disease. An echocardiogram will be done 3-4 weeks after the first one to watch for changes in the arteries of the heart. The disease has a long recovery time, and the child may need to take aspirin for three months or more. Fortunately, if treatment is started early in the disease, the child will, in most cases, avoid heart complications.
Children with Kawasaki disease generally are irritable and uncomfortable. Fever is usually high and spiking, exceeding 102ºF in almost all and 104ºF in many cases. Antipyretics have little impact. The febrile course persists as long as 3 to 4 weeks without definitive treatment. Conjunctival injection is more prominently bulbar than palpebral without associated exudates or ulceration. Mild anterior uveitis is often evident on slit lamp examination and resolves without sequelae.
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To diagnose Kawasaki disease, the doctor first needs to check if your child has other diseases that might cause similar symptoms. If your child has had a fever for many days and ... has four or five of the other symptoms listed above, then the doctor will probably diagnose your child with Kawasaki disease. A diagnosis of "a typical Kawasaki syndrome" may be made if your child has a fever and fewer than four of the symptoms.
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INTRODUCTION — Kawasaki disease (KD) is a vasculitis of infancy and early childhood. It was first described by Dr Tomisaku Kawasaki in 1967, and initially designated as the mucocutaneous lymph node syndrome [1]. KD is an immune-mediated vasculitis with self-limited clinical course and unknown etiology.
Children with Kawasaki disease should be hospitalized and cared for by a physician who has experience with this disease. When in an academic medical center, care is often shared between pediatric cardiology and pediatric infectious disease specialists, although no infectious agent has been demonstrated. It is imperative that treatment be started as soon as the diagnosis is made to prevent damage to the coronary arteries.
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