LYCOS RETRIEVER 
Isis
built 184 days ago
Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 18 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Ibis Biosciences, Inc., Isis' wholly owned subsidiary, is developing and commercializing the Ibis T5000(TM) Biosensor System, a revolutionary system to identify infectious organisms. Isis is a joint owner of Regulus Therapeutics LLC, a joint venture focused on the discovery, development and commercialization of microRNA therapeutics.
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Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 15 drugs in development. Isis' drug development programs are aimed at treating cardiovascular, metabolic and inflammatory diseases. Isis' partners are focused in disease areas such as ocular, viral and neurodegenerative diseases, and cancer. In its Ibis Biosciences(TM) division, Isis is developing and commercializing the Ibis T5000(TM) Biosensor System, a revolutionary system to identify infectious organisms. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of approximately 1,500 issued patents worldwide.
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Isis has had an extensive oligonucleotide medicinal chemistry program since its inception and it continues to lead the field in the development of RNA-based drugs. Isis inventions in oligonucleotide chemistry enable improved stability, potency, distribution and safety of antisense drugs and are the basis for a portion of the Company's industry-leading intellectual property position.
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Isis later had an important cult in the Greco-Roman world, with sanctuaries at Delos and Pompeii. To the Greeks she was known as Demeter - to the Romans as Ceres - though she played other goddess roles in all ancient civilizations.
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As part of the collaboration, Isis licensed to Bristol-Myers Squibb exclusive access to its PCSK9 research program. This program has recently produced new data shedding light on the mechanism by which PCSK9 contributes to high levels of low density lipoprotein (LDL) cholesterol. With its second- generation antisense PCSK9 compounds, Isis has shown in mice that reducing PCSK9 leads to increased levels of LDL receptor and consequently to lower LDL- cholesterol in the bloodstream. Decreasing LDL-cholesterol is thought to play a key role in reducing the risk of coronary artery disease.
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In April 2006, Isis announced initial data from the three low-dose cohorts of a Phase 2 clinical trial of ISIS 301012 as a single-agent in patients with high cholesterol. ISIS 301012 produced rapid, dose-dependent and prolonged reductions of its target, apoB-100, with concomitant reductions in LDL, VLDL, total cholesterol and triglyceride levels in patients with high cholesterol. At a dose of 200 mg/wk for three months, ISIS 301012 achieved a median percent reduction from baseline of 47% in apoB-100, 42% in LDL, 34% in total cholesterol and 46% in triglycerides at day 99. Isis is continuing this Phase 2 single-agent trial using higher dosing (300 and 400 mg/wk) of ISIS 301012.
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