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Irritable Bowel Syndrome: Disorders
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Some believe that one major cause of Irritable Bowel Syndrome could be heavy metal toxicity, particularly from mercury dental amalgams. Others suggest that IBS may occur from overuse of antibiotics, food allergies, nutritional deficiencies (particularly a lack of magnesium), and/or chronic fungal infection, such as Candida. IBS may ... stem from hypercoagulability, or thick blood, a circulatory disorder that lowers the blood flow to the small and large intestines.
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As many as one in five adults in the United States has irritable bowel syndrome (IBS). It is a functional disorder, which means that there are no structural abnormalities seen on x-ray, endoscopy, or blood tests.
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The CRF collaboration between Neurocrine and GlaxoSmithKline (GSK) has identified multiple unique high affinity and selective antagonists for the CRF1 receptor that are currently in clinical development for anxiety-related disorders and irritable bowel syndrome (IBS). GSK is conducting two Phase II "proof of concept" clinical trials with a lead CRF1 receptor antagonist compound, 876008, for two indications, social anxiety disorder (SocAD) and IBS. Data from the clinical trial in SocAD is expected to be reported at the end of 2007.
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IBS is a "functional" disorder, which means that the bowel doesn't work as it should. The cause of IBS is not known, and there is no cure for IBS. But, there are things you can do to feel better. For more information, see the question "What is the treatment for IBS?" in this FAQ.
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