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Inspra
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Genetic tests may eventually further boost Inspra's market share. On Jan. 15, Pharmacia announced an alliance with Reykjavik, Iceland-based DeCode Genetics (nasdaq: DCGN - news - people ) to find genes that predispose people to progress from early forms of heart disease to later ones. Pharmacia and DeCode will run clinical trials to see if people with these markers benefit from being put on Inspra or other cardiac drugs being developed by Pharmacia.
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Dosing/Administration: The recommended starting dose of Inspra® is 50 mg administered once daily. The full therapeutic effect is apparent within 4 weeks. For patients with an inadequate blood pressure response to 50 mg once daily the dosage should be increased to 50 mg twice daily.3
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Before the merger in 2002, analysts had been forecasting that Inspra could become a billion-dollar pill. Instead, sales in the second quarter of this year were a tiny $1 million. In a transcript of the New York-based firm's first-quarter conference call, Morgan Stanley analyst Jami Rubin summed it up: "It seems like Inspra is a big flop."
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The popularity of names like Aldara, Inspra, and Lunesta reflects the rise in direct-to-consumer advertising. These names are nonthreatening, which makes it easier to talk about serious conditions and to request a prescription.
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You cannot take Inspra for high blood pressure if you ... take potassium-sparing diuretics such as amiloride, spironolactone, and triamterene. Likewise, this drug cannot be used to treat high blood pressure if you have type 2 diabetes along with high protein levels in the urine (known as microalbuminuria), a condition that could signal kidney problems.
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Inspra has been evaluated for safety in 3091 patients treated for hypertension. A total of 690 patients were treated for over 6 months and 106 patients were treated for over 1 year.
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