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Inspra
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Inspra may even be one of the drugs that got New York City-based Pfizer interested in buying Pharmacia in the first place. Pfizer is a world leader in medicines for heart problems, including Lipitor and Norvasc, a high blood pressure drug that Pfizer boasts in advertisements is the world's most-prescribed cardiovascular agent. A new, first-in-class hypertension drug must be appealing.
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Inspra is a prescription drug for adults who develop congestive heart failure after a heart attack. Congestive heart failure means the heart is too weak to pump enough blood through the body. Inspra can help these patients survive. It can be used with other heart medicines and can ... be taken by adults with high blood pressure. It lowers blood pressure by itself or with other medicines.
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Inspra contains eplerenone, a blocker of aldosterone binding at the mineralocorticoid receptor. INSPRA is indicated to improve survival of stable patients with left ventricular systolic dysfunction (ejection fraction 40%) and clinical evidence of congestive heart failure after an acute myocardial infarction. INSPRA tablets contain 25 mg or 50 mg of eplerenone. The principal risk of INSPRA is hyperkalemia. Hyperkalemia can cause serious, sometimes fatal, arrhythmias. This risk can be minimized by patient selection, avoidance of certain concomitant treatments, and monitoring.
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Could Inspra stage a recovery? Pfizer could use another blockbuster, with some of its lesser drugs going generic. It has deep expertise in larger heart disease markets and touts hypertension drug Norvasc as the most prescribed high blood pressure medicine, while its cholesterol pill Lipitor is the world's most lucrative drug. That's true even with other giants such as Merck (nyse: MRK - news - people ), Novartis (nyse: NVS - news - people ) and AstraZeneca (nyse: AZN - news - people ) competing for patients. But heart failure is a different market, and Pfizer's cardiovascular salesmanship may not extend into this niche.
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Inspra is usually not used in patients with moderate to severe kidney problems. Medications such as spironolactone, triamterene and amiloride should be stopped prior to starting Inspra. Also, potassium supplements may need to be stopped to prevent increases in serum potassium levels.
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Inspra is used for treating high blood pressure and/or improving survival rates in patients who have left ventricular systolic dysfunction and congestive heart failure following a heart attack. It is sometimes used with other medicines. It may ... be used for other conditions as determined by your doctor.
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