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Inspra: High Blood Pressure
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EPLERENONE (Inspra™) helps to lower blood pressure. It controls high blood pressure, but it is not a cure. High blood pressure can damage your kidneys and can cause a stroke or heart failure. Blood pressure treatment might help prevent these complications. Eplerenone can ... be used to improve symptoms of heart failure. Generic eplerenone tablets are not yet available.
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Among patients who had suffered an acute heart attack, Inspra reduced the risk of death by 15percent in human trials, the FDA says. First approved in 2002 for people with high blood pressure, Inspra is the first in a class of drugs called aldosterone receptor blockers to be agency-sanctioned for congestive heart failure.
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Inspra is indicated for the treatment of hypertension (high blood pressure) and may be used alone or in combination with other anti-hypertensive agents. Inspra is ... being studied for use in heart failure; as a selective aldosterone receptor antagonist, Inspra may offer advantages over currently available non-selective aldosterone antagonists.
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Inspra is prescribed to improve survival in patients who have congestive heart failure and left ventricular systolic dysfunction following a heart attack. It is ... used to treat high blood pressure. Inspra may be used alone or with other antihypertensive agents. Inspra lowers blood pressure by blocking the actions of the hormone aldosterone.
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Inspra was demonstrated to be effective in lowering high blood pressure in over 3,000 patients and was generally well tolerated. Patients treated with Inspra 50 to 200 mg daily experienced significant decreases in sitting systolic and diastolic blood pressure at trough with differences from placebo of 6-13 mm Hg (systolic) and 3-7mm Hg (diastolic). These effects were confirmed by assessments with 24-hour ambulatory blood pressure monitoring (ABPM).
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Until now, Peapack, N.J.-based Pharmacia (nyse: PHA - news - people ), which is expected to close its merger with Pfizer (nyse: PFE - news - people ) by the end of the year, has kept things relatively quiet on Inspra. But the drug could be as important as the company's current bestseller, the arthritis treatment Celebrex. Of the 50 million Americans who have high blood pressure, 73% don't have the disease adequately controlled. Moreover, Inspra may ... prove useful in treating heart failure, further increasing the size of its market.
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