LYCOS RETRIEVER 
Inspra: Heart
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Inspra is a mineralocorticoid receptor blocker. It works by blocking aldosterone. This widens blood vessels and reduces fluid and sodium retention, lowering blood pressure to help prevent strokes, heart attacks, and kidney problems.
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Inspra is a mineralocorticoid receptor blocker. Its function is to block aldosterone. This aids in widening of the blood vessels and causes a reduction in sodium and fluid retention, reduces blood pressure, thereby preventing heart attacks, strokes or kidney problems.
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Inspra helps most people with heart failure, but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
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In big clinical trials, both spironolactone and Inspra were shown to improve the survival of heart failure patients. But in yesterday's issue of The New England Journal of Medicine, researchers published a study showing that patients on spironolactone were more likely to die from hyperkalemia. The study advocates watching patients more closely and using spironolactone more judiciously.
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Inspra is usually administered together with other medication for heart failure eg beta blockers. The usual starting dose is one 25 mg tablet once daily, increasing after about 4 weeks to 50 mg once daily (either as one 50 mg tablet or two 25 mg tablets).
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