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Inflammation: Chronic Inflammation
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Inflammation is what causes arthritic pain, stiffness when using your muscles, the wheezing of asthma and the discomfort of allergies. It is even possible that the progression of atherosclerosis is directly related to chronic inflammation in up to 50 percent of cases. Excess acid production ... increases the inflammatory response leading to loss of bone and joint tissues.
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Inflammation can be acute or chronic. When it is acute, it occurs as an immediate response to trauma (an injury or surgery)—usually within two hours. When it is chronic, the inflammation reflects an ongoing response to a longer-term medical condition, such as arthritis.
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Inflammation normally subsides on its own... if the symptom is long-lasting it can be called chronic inflammation. If you suspect a chemical is causing inflammation, avoid exposure and see if the inflammation subsides.
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VP015 is one of a series of structurally related drugs that are designed to interact with immune cells leading to the modulation of cytokines - potent chemical messengers that regulate and control inflammation. VP025, the lead product candidate from this new class of drugs, is being developed for the treatment of certain chronic neurological disorders. Neurological conditions that are associated with an inflammatory response in the brain and central nervous system include Alzheimer's disease, Parkinson's disease, ALS (Lou Gehrig's disease) and multiple sclerosis. These indications are characterized by increased levels of inflammatory mediators, including cytokines, leading to the death of nerve cells and the eventual loss of functional activity. Due to the prevalence, morbidity and mortality associated with neuro-inflammatory diseases, they represent a significant medical, social, and financial burden.
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In recent years, clinical and scientific knowledge of asthma has evolved from a model of episodic constriction of bronchial smooth muscle to a model which involves chronic airway inflammation. Evidence of inflammation is present at the onset of symptoms in newly diagnosed asthmatic patients. Accordingly, treatment algorithms for asthma have emphasized treatment of the underlying inflammation, as well as the bronchoconstrictive symptoms. By acquiring a better understanding and appreciation of the inflammatory process, physicians can employ treatments to inhibit specific steps in the process and improve control over asthma and its symptoms.
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Acute inflammation lasts at most only a few days. The treatment of acute inflammation, where therapy typically includes the administration of aspirin and other non-steroidal anti-inflammatory drugs, provides relief of pain and fever for patients. In contrast, chronic inflammation lasts weeks, months or even indefinitely and results in tissue damage. In chronic inflammation, the inflammation becomes the problem rather than the solution to infection, injury or disease. Chronically inflamed tissues continue to generate signals that attract white blood cells from the bloodstream. When white blood cells migrate from the bloodstream into the tissue they amplify the inflammatory response.
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Chronic Inflammation