LYCOS RETRIEVER 
Inflammation: Blood
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Vasculitis, an inflammation of the blood vessels, was observed in animals that received very high doses of capravirine in the 12-month toxicology study; this finding was not seen in previously conducted animal safety studies. Pfizer is working closely with the FDA to conduct additional animal toxicology studies to further evaluate the safety profile of capravirine. To date, no cases of vasculitis have been detected in patients receiving capravirine in the Pfizer trials.
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Atherosclerosis is the result of chronic inflammation and the buildup of plaque in arterial blood vessel walls. Plaque consists of inflammatory cells, cholesterol and cellular debris. Atherosclerosis, depending on its severity and the location of the artery it affects, may result in a heart attack or stroke.
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Studies suggest inflammation in the blood vessels may be linked to atherosclerosis, or fatty build-up in the blood vessels, which can increase your risk of coronary artery disease and stroke. Also, inflammation of the heart itself causes fluid retention and shortness of breath.
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Various leukocytes are critically involved in the initiation and maintenance of inflammation. These cells must be able to get to the site of injury from their usual location in the blood, therefore mechanisms exist to recruit and direct leukocytes to the appropriate place. The process of leukocyte movement from the blood to the tissues through the blood vessels is known as extravasation, and can be divided up into a number of broad steps:
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ACE inhibitors, drugs commonly used to treat high blood pressure... appear to reduce inflammation. The drugs help prevent heart attacks, strokes and the complications of diabetes, possibly because they block the action of angiotensin, a protein that not only constricts blood vessels but also seems to promote inflammation.
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C-reactive protein (CRP), a marker of systemic low-grade inflammation, is frequently elevated in essential hypertension. In one study of 36 subjects with essential hypertension, 36 subjects with white coat hypertension (blood pressure that rises only in the doctor’s office), and 36 subjects without hypertension, CRP levels were significantly higher in the essential hypertensive and white-coat hypertensive groups than in the group with normal blood pressure. It was ... higher in the essential hypertensive group than in the white-coat hypertensive group.6
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