LYCOS RETRIEVER 
Inflammation: Asthma
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Ongoing research has identified numerous cells and mediators that may be involved in the airway inflammation associated with asthma. The multiplicity of these cells and substances points to the complexity of the disease and to the many unanswered clinical and research questions that await clarification in further research. Key inflammatory cells and mediators identified ... far include:
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In asthma, increased levels of adenosine can overactivate the A2B- adenosine receptor leading to mast cell degranulation and the release of inflammatory cytokines associated with bronchoconstriction and chronic lung inflammation. CVT-6883 may provide a potentially novel approach to preventing or reducing this inflammatory process by selectively inhibiting the A2B- adenosine receptor.
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A number of models have been developed to explain inflammation. One that seems especially pertinent to asthma is the inflammatory cascade, outlined below. The model suggests that asthma-associated inflammation occurs as a seven-step process:
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It is not just age-related disease that has been linked to chronic inflammation. A growing body of evidence points to a chronic inflammatory state as an underlying cause of kidney failure, asthma, pancreatitis, lupus, certain skin diseases, and other conditions.
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High levels of nitric oxide have ... been implicated in the inflammation that is associated with asthma. Asthmatics exhale significantly higher levels of nitric oxide and type II nitric oxide synthase (also known as "NOS") expression is increased in biopsy specimens from asthmatics.
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Asthma