LYCOS RETRIEVER 
Indomethacin
built 646 days ago
Indomethacin-induced G1 arrest and apoptosis of human colorectal cancer (CRC) cells is associated with a dose-dependent decrease in ß-catenin protein levels. ß-catenin plays a pivotal role in the WNT signalling pathway and its expression is frequently dysregulated at early stages of colorectal carcinogenesis. The objective of this study was to investigate the effect of indomethacin on catenin expression and downstream WNT signalling events in human CRC cells. ß-catenin, -catenin and T-cell facter (TCF) target gene (cyclin D1, c-MYC and PPAR) expression was studied following indomethacin treatment of SW480 and HCT116 cells. Cyclin D1 was used as a model TCF target gene for analysis of ß-catenin–TCF-4 DNA binding and trans-activation. Indomethacin treatment was associated with a specific decrease in ß-catenin (but not -catenin) expression.
Source:
Indomethacin is used to treat patent ductus arteriosus and, on a different dosing schedule, to prophylactically decrease the risk of intraventricular hemorrhage. PDA in infants with RDS complicates mechanical ventilation, and is associated with BPD, decreases in cerebral, mesenteric, and renal blood flow, and CHF. Indomethacin, by inhibiting prostaglandin synthesis, allows the ductus to constrict in a high proportion of treated infants. Reversible renal insufficiency often occurs and fluid status must be carefully watched. Because significant oliguria can occur, fluids may need to be restricted to prevent fluid overload and dilutional hyponatremia. Do not follow BUN/Cr during Indomethacin therapy as they predictably rise.
Source:
Indomethacin comes as a capsule, an extended-release (long-acting) capsule, and a suspension to take by mouth and as a suppository to be used rectally. Indomethacin capsules, liquid, and suppositories usually are taken two to four times a day. Extended-release capsules are usually taken one or two times a day. Indomethacin capsules, extended release capsules, and suspension should be taken with food, immediately after meals, or with antacids. Take indomethacin at around the same times every day.Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take indomethacin exactly as directed.
Source:
Since one major favorable argument for acquiring your MICROCID (Indocin, Indomethacin) online is the cost, then by all means fill up your prescription and buy up to three months’ supply! This saves you both time and money and ensures that you have your prescription available to you when you need it!
Source:
Indomethacin can be taken by mouth or as a rectal suppository. Indomethacin comes as a capsule, extended–release capsule, or liquid. Do not open or crush the extended release capsule. Shake the liquid before pouring the dose. Take the medicine 3 to 4 times a day as directed with food, milk, or antacid to protect your stomach. To take the rectal suppository, open the package and dip the tip in water.
Source:
Indomethacin suppositories are put into the rectum (back passage). Follow the directions on the prescription label. Wash your hands. Take off the foil wrapping. Wet the tip of the suppository with water to make it easier to use. Lie on your side and raise your knee to your chest.
MORE ABOUT
Indomethacin