LYCOS RETRIEVER 
Indomethacin: Effects
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Indomethacin readily crosses the placenta, and can reduce fetal urine production to treat polyhydramnios. It does so by reducing renal blood flow and increasing renal vascular resistance, possibly by enhancing the effects of vasopressin on the fetal kidneys.
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Indomethacin may ... be helpful in headache related to physical stress or exertional headache. It has been shown to be effective in migraine both for prevention of migraine as well as treating the acute migraine attack.
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If Indomethacin is taken with certain other drugs, the effects of either could be increased, decreased or altered. It is especially important to check with your doctor before combining Indomethacin with the following:
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Indomethacin was given in a dose of 2.2-3 mg/kg/day (75 mg twice daily). The changes in the following parameters were evaluated to determine the effect of indomethacin therapy a) maternal symptoms and uterine contractions; b) weekly measurement of fundal height and abdominal girth at the level of the umbilicus and serial ultrasound (to monitor foetal growth and amniotic fluid); and c) prolongation of pregnancy.
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