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Imitrex
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Imitrex Injection should only be used where a clear diagnosis of migraine or cluster headache has been established. Imitrex Injection is indicated for: 1) the acute treatment of migraine attacks with or without aura; and 2) the acute treatment of cluster headache episodes. Care should be taken to exclude other potentially serious neurologic conditions before treating headache in patients not previously diagnosed with migraine or cluster headache or who experience a headache that is atypical for them. There have been rare reports where patients received sumatriptan for severe headaches that were subsequently shown to have been secondary to an evolving neurologic lesion. For a given attack, if a patient does not respond to the first dose of sumatriptan, the diagnosis of migraine or cluster headache should be reconsidered before administration of a second dose.
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The long-term use of Imitrex Injection for cluster headache has been evaluated in two open-label studies. Sumatriptan was found to be well tolerated and effective in the long-term treatment (up to 1 year) of cluster attacks. There was no evidence of tachyphylaxis or an increased incidence of adverse events over time.
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