LYCOS RETRIEVER 
Human Growth Hormone: Pituitary Gland
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Growth Hormone promotes liver's secretion of growth factor IGF-1 and revitalizes cells and organs to return to their original conditions. Growth Hormone is the ultimate hormone secreted by the pituitary gland. It is closely associated with the production of male hormones.
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Human growth hormone, secreted by the pituitary gland which is located in the center of the brain, peaks during adolescence when growth is most rapid. It is the primary hormone responsible for maintaining physical and mental health through tissue repair, healing, cell replacement, bone strength, brain function, enzyme production, integrity of the hair, nails and skin. By the age of 60 it is not uncommon to see declines in the order of 75% from more youthful levels.
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The notion of a growth hormone arose from clinical observations on gigantism and acromegaly. Gigantism is a condition caused by too much GH in childhood and marked by much greater height than usual. Acromegaly is caused by too much GH in adulthood and is marked by a thickening of the bones in the feet, hands, and face. In the 1930s, American biologist Herbert Evans (1882-1971) demonstrated how extracts from the pituitary gland can greatly stimulate animal growth, producing gigantism.
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Norditropin® (somatropin [rDNA origin] for injection) Indicated for long-term treatment of children with growth failure due to inadequate secretion of endogenous growth hormone normally produced in the pituitary gland. Mfg: Novo Nordisk. Source: PR Newswire - 2/20/97.
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It is scientifically well proven that secretion of growth hormone by the pituitary gland decreases progressively with age. Starting after adolescence, secretion of growth hormone steadily declines until the amount present in older people is a small fraction of younger levels, often less than 10%. This is one cause of many adverse effects of aging, including the following:
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Acromegaly is a condition caused by an excess of growth hormone. The most obvious sign of acromegaly is the overgrowth of bones in the face, hands and feet. People between 30 and 50 years are most commonly affected. A benign tumour on the pituitary gland is the most common cause.
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Pituitary Gland