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Human Genome Project: Environmental Research
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During 1992 discussions of Human Genome Diversity ... took place in several other contexts under the auspices of HUGO. These included the Human Genome 92 meeting in Nice (France), the second HUGO Europe meeting in Sardinia (Italy) and the first South/North Human Genome Meeting in Brazil. Discussions in the latter meeting emphasised the value of genome diversity studies for involving developing countries in human genome research through an interest in their own populations and diseases.
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The Human Genome Research project is considered by many to be one of the largest undertakings in the history of science. Dr. Collins led the successful completion of the 13-year-long project, and developed techniques to map and identify genes responsible for the diseases of cystic fibrosis, neurofibromatosis, Huntington's disease and Hutchison-Gilford progeria syndrome.
A team out of the University of Southampton recently announced that they have successfully applied a cost-effective technique to scan the human genome for genetic mutations. The scanning device, meltMADGE, "combines thermal ramp electrophoresis with microplate array diagonal gel electrophoresis." A team of British medical researchers used meltMADGE to scan the genes of about 10,000 individuals for mutations associated with cholesterol blood levels.
The DOE Office of Biological and Environmental Research is receiving applications in support of the Ethical, Legal, and Social Implications (ELSI) component of the Human Genome Program. Applications should focus on issues of genetics and the workplace, storage of genetic information and tissue samples, education, or complex or multigenic traits.
Sequencing the genomes of other organisms can yield insights into the human genome. Scientists can often identify aging-related genes in simpler organisms. Subsequent comparison to the human genome can often help researchers identify similar genes in humans, helping them target their inquiries more effectively.
As for policy, the private sector ventures are provoking intense scrutiny of the federally-supported Human Genome Project. Private efforts are ... inflaming passions about control of the genome and the extent to which mining the genome for profits will help or hurt biomedical research and medical advances.
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