LYCOS RETRIEVER
Hepatitis C: Studies
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Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: a multicenter, retrospective cohort study of 1124 patients. Kobayashi S, et al. Liver Int. 2007 Mar;27(2):186-91.
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A major focus of hepatitis C research is development of a cell culture through which scientists can study HCV outside the human body. By understanding how the virus replicates and how it injures cells, researchers may be able to develop ways to control the virus as well as drugs to block it.
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One exception is Cambridge, Mass.-based Vertex Pharmaceuticals Inc., which plans on starting a late-stage study for its hepatitis C drug candidate telaprevir in March, with its partner Johnson & Johnson. Vertex shares fell 19 cents to $18.43, while Johnson & Johnson shares fell 52 cents to $62.52.
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Data from a small phase II study conducted in Egypt on hepatitis C patients with genotype 4 will be presented later this week, but results were made public Friday. The company is starting a new study in Genotype 1 patients (more prevalent here and in Europe) soon.
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Effect of iron depletion on serum markers of fibrogenesis, oxidative stress and serum liver enzymes in chronic hepatitis C: results of a pilot study. Alexander J, et al. Liver Int. 2007 Mar;27(2):268-73.
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Oxymatrine was selected for study because it had previously been shown to inhibit viruses (including hepatitis B), enhance cellular immune functions, and reduce liver fibrosis. Sophora subprostrata has been an ingredient in many hepatitis B formulas (given orally in decoction form). Sophora-root-extract injection has been used experimentally and clinically for a variety of disorders at least since 1976. Usual dosages are 200-400 mg per day, though up to 800 mg is given by injection in two divided doses. The tablet of sophora extract has ... been administered; an example of the dosage used is 1.5 grams each time (presumably about 20% alkaloids, thus 450 mg), three times daily.
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