LYCOS RETRIEVER 
Hepatitis C: Disease Control
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Biolex has selected hepatitis C as the first indication for the commercialization of its alfa interferon program. In February of 2005, Biolex formed a partnership with OctoPlus, a drug delivery and development company based in the Netherlands, for the joint development of a controlled-release formulation of alfa interferon. The product under joint development, Locteron(TM), combines BLX-883 with OctoPlus' proprietary biodegradable PolyActive(TM) drug delivery technology, and is designed to be a best-in-class therapeutic for patients with chronic hepatitis C.
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The goals of chronic hepatitis B treatment are sustained suppression of HBV and an end to active liver disease. Patients with HBeAg-positive chronic hepatitis who have a substantial decrease in the level of HBV DNA and a loss of HBeAg at the end of therapy are considered to have had a virologic response to treatment. A sustained response is one that persists for 6-12 months after therapy ends. Patients who have a sustained loss of HBsAg are deemed to have a complete response to antiviral therapy, but this does not happen very often.
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According to the Centers for Disease Control and Prevention, people traveling to countries where hepatitis A is common should consider getting immunized. There is an effective vaccine that virtually eliminates the possibility of getting hepatitis A.
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Tattooing has been shown to transmit infectious diseases, including hepatitis B and C, syphilis, leprosy and tuberculosis. Small outbreaks of hepatitis have been identified in customers visiting certain commercial tattoo parlors on the same day.
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Post-load insulin resistance is an independent predictor of hepatic fibrosis in Virus C Chronic Hepatitis and in Nonalcoholic Fatty Liver Disease. Svegliati-Baroni G, et al. Gut. 2007 Mar 28 [Epub ahead of print].
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An important factor to consider in the treatment of hepatitis C with alpha interferon is the psychological make-up of the patient. Alpha interferon has multiple neuropsychiatric effects, again according to the National Digestive Diseases Information Clearinghouse article.
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