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Hemophilia: Blood
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Hemophilia A is an X-linked, hereditary bleeding disorder caused by the absence or defect of a blood clotting protein, Factor VIII. As a result, when a person with hemophilia A has a bleeding episode, the bleeding may be prolonged due to the body's inability to form blood clots. Patients who are affected with hemophilia A experience frequent spontaneous bleeding, most commonly into their joints and soft tissues, with bleeding into vital organs that may ... be life-threatening. Bleeding episodes may be painful, and over time, recurrent joint bleeding may result in debilitating destruction of the joints. Currently, patients with hemophilia A are dependent on injections of Factor VIII produced by genetic engineering or purified from human plasma, to help control a bleeding episode. It is estimated that approximately 50,000 individuals worldwide are affected with hemophilia A.
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Hemophilia is a rare inherited disorder in which the blood does not clot normally. About 18,000 people in the U.S. have hemophilia. Each year, about 400 babies are born with the disorder. Hemophilia usually occurs in males (with very rare exceptions).
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Hemophilia A and hemophilia B are genetic disorders in the blood-clotting system, characterized by bleeding into joints and soft tissues, and by excessive bleeding into any site experiencing trauma or undergoing surgery. Hemophilia A and B are clinically indistinguishable. Both have the same type of bleeding manifestations, and both affect males almost exclusively. The two conditions can be distinguished by detecting the responsible defective proteins.
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A: Hemophilia is a hereditary disease in which the blood does not clot properly. It is caused by a deficiency in one of the substances (clotting factors) needed for normal blood clotting. This deficiency is due to a sex-linked recessive genetic defect.
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Hemophilia B is ... known as Factor IX Deficiency. Another name for Hemophilia B is Christmas Disease, named for the patient in whom the problem was first defined. Patients with Hemophilia B do not have enough blood-clotting protein known as Factor IX.
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Hemophilia is the most common inherited bleeding disorder. It involves a deficiency of one of two blood-clotting substances, known as factor VIII and factor IX, and leads to the inability of the blood to clot. There are two types of hemophiliac—type A and type B—but the symptoms are the same in both types. There are about 20,000 people in the United States who have hemophilia.
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