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Gout: Uric Acid
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Gout is caused by the buildup of uric acid in the joints. According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases, approximately 18% of people who develop gout have a family history of the condition. Diseases and conditions that increase the risk include diabetes, obesity, kidney disease, and sickle cell anemia.
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Gout is caused by too much uric acid in the blood. Most of the time, having too much uric acid is not harmful. Many people with high levels in their blood never get gout. But when uric acid levels in the blood are too high, the uric acid may form hard crystals in your joints.
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Gout occurs when mono-sodium urate crystals form on the articular cartilage of joints, on tendons, and in the surrounding tissues. Purine metabolism gives rise to uric acid, which is normally excreted in the urine. Uric acid is more likely to form into crystals when there is a hyperuricemia, although it is 10 times more common without clinical gout than with it.[3]
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Gout is a form of arthritis caused by high levels of uric acid in the blood, tissues, and urine. The uric acid can form crystals which collect in joints such as the big toe. In fact, your big toe can become so painful and swollen that even the weight of a bedsheet can be agonizing.
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Gout is a disease that results from an imbalance between the production of uric acid (a break-down product of protein digestion), and the ability to excrete this substance, which is mainly a function of the kidneys. Why this imbalance and the resulting excess of uric acid in the blood, and often ... in tissues, causes symptoms only intermittently is still being investigated.
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Gout is an inflammatory condition that is caused by the deposit of uric acid crystals in joints (most famously the big toe) as well as other tissues. Typically, attacks of fierce pain, redness, swelling, and heat punctuate pain-free intervals.
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