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Glucosamine: Studies
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Glucosamine is a nutritional supplement. Glucosamine may improve symptoms of pain and stiffness in some patients with osteoarthritis, according to recent research studies. In one study, glucosamine was compared to ibuprofen (ADVIL, MEDIPREN, MOTRIN, NUPRIN.) Pain relief was more rapid with ibuprofen 400mg three times daily than with glucosamine 500mg three times daily; ... after 4 weeks the relief of symptoms was similar with the two treatments. (Of note, this dose of ibuprofen is not an antiinflammatory dose; higher amounts are typically given.)
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Objective: Glucosamine, classified as a slow-acting drug in osteoarthritis (SADOA), is an efficacious chondroprotective agent. Methylsulfonylmethane (MSM), the isoxidised form of dimethyl-sulfoxide (DSMO), is an effective natural analgesic and anti-inflammatory agent. The aim of this study was to compare the efficacy and safety of oral glucosamine (Glu), methylsulfonylmethane (MSM), their combination and placebo in osteoarthritis of the knee.
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Glucosamine might ... be helpful for rheumatoid arthritis , according to a double-blind, placebo-controlled study of 51 people. 59 In this study, use of glucosamine at a dose of 1,500 mg daily significantly improved symptoms. It did not, however, alter measures of inflammation as determined through blood tests.
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This was a study that reviewed other studies that have taken place on Glucosamine, Ibuprofen (a NSAID) and placebo. In every study, Glucosamine was shown to be always be more effective than placebo and be atleast as effective (if not more so) than Ibuprofen, which carries risks when it is used for long periods of time. Overall, Glucosamine has been shown to be an effective therapeutic nutraceutical for certain kinds and locations of arthritis with almost no side effects.
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