LYCOS RETRIEVER 
Genetics
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CGI's cutting-edge chemical genetics approach is based on the discovery of Analog Sensitive Kinase Alleles (ASKAs). ASKAs are genetically modified kinases that retain all the functions of normal kinases, but can be potently inhibited with exquisite selectivity and specificity by a specially designed proprietary small molecule analog inhibitor. This enables drug discovery scientists to quickly understand the pharmacological consequences of specific kinase inhibition and, therefore, the likely therapeutic benefit of inhibiting the normal kinase target with a small molecule drug. CGI holds the exclusive worldwide license to this broadly enabling chemical genetics technology, which has powerful applications to multiple facets of the drug discovery process. These include: cell pathway based target identification; rigorous, pharmaceutically relevant in vivo target validation; proprietary high-content cell-based drug screens; and in vivo systems that provide key therapeutic index and drug safety information to guide the selection of optimal drug candidates for clinical development.
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An Augustinian monk named Gregor Mendel, born in 1822 in the town of Heinzendorf, Austria, discovered the principals of genetics during the 1860's. His theories, proven today, said that there are two genes for each trait, one inherited from each parent. They can be the same trait or different. If they are different, one can be dominant and will be seen in the organism. If the gene is recessive, the effect is hidden and therefore not seen in the organism.
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Over the past decade the face of genetics has changed. The quantity of data that is being produced, coupled to an increase in computational power, means that information can be stored and analyzed to an unprecedented degree. Fields as disparate as population genetics, systems biology and the mathematical modeling of development rely on quantitative descriptions, and statistical analysis — once a concept foreign to mainstream genetics — is pervading every aspect of the field.
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Genetics is the study of heredity. If you understand genetics you will be able to work out why you look like each of your parents and your siblings (brothers and sisters) but are not exactly like any one of them: unless you have an identical twin.
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The modern science of genetics traces its roots to the observations made by Gregor Johann Mendel, a German-Czech Augustinian monk and scientist who made detailed studies of the nature of inheritance in plants. In his paper "Versuche über Pflanzenhybriden" ("Experiments on Plant Hybridization"), presented in 1865 to the Brunn Natural History Society, Gregor Mendel traced the inheritance patterns of certain traits in pea plants and showed that they could be described mathematically.[4] Although not all features show these patterns of Mendelian inheritance, his work suggested the utility of the application of statistics to the study of inheritance.
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Work is offered for the master of science [M.S.] and doctor of philosophy [Ph.D.] degrees with a major or minor in genetics. There are thirteen participating departments and they are all listed on the right.
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Genetics