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Genetics: Molecular Genetics
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Genetics is the study of the causes and consequences of inherited differences among individuals. It encompasses the molecular, cellular, organismal and populational levels over time spans ranging from a 20-minute bacterial division to 4 billion years of evolution.
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The Department of Molecular Biology and Genetics shares a leading role in research and teaching in modern biology at Cornell University. The department has over 35 faculty and is housed in the Biotechnology Building, a state-of-the-art facility with individual laboratories and core research facilities.
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Trains graduates for rapidly expanding careers in Genetics: at academic institutions, biotechnology and pharmaceutical companies, private research institutes, and governmental research laboratories. Training in the Genetics Program encompasses the full spectrum from the molecular to the population level in a wide range of model systems.
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Population, quantitative and ecological genetics are all very closely related subfields and ... build upon classical genetics (supplemented with modern molecular genetics). They are chiefly distinguished by a common theme of studying populations of organisms drawn from nature but differ somewhat in the choice of which aspect of the organism on which they focus. The foundational discipline is population genetics which studies the distribution of and change in allele frequencies of genes under the influence of the four evolutionary forces: natural selection, genetic drift, mutation and migration. It is the theory that attempts to explain such phenomena as adaptation and speciation.
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The field of molecular genetics describes the basis of inheritance at the molecular level. It focuses on two general questions: how do genes specify the structure and function of organisms, and how are genes replicated and transmitted to successive generations? Both questions have been answered. Genes specify organismal structure and function according to a process described by the central dogma of molecular biology: DNA is made into messenger ribonucleic acid (mRNA), which specifies the structure of a protein; the mRNA molecule then serves as a template for protein synthesis, which is carried out by complex machinery that comprises a particle called a ribosome and special adapter RNA molecules called transfer RNA. See ... Deoxyribonucleic acid (DNA); Ribonucleic acid (RNA); Ribosomes.
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EpiCept's proprietary apoptosis screening technology can efficiently identify new cancer drug candidates and molecular targets that selectively induce apoptosis in cancer cells through the use of chemical genetics and its proprietary live cell high-throughput caspase-3 screening technology. Azixa represents the first confirmed clinical proof of concept for this new technology, which is the basis for the company's oncology drug discovery efforts.
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Molecular Genetics