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Genetics: Human Genetics
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The Department of Human Genetics is the youngest basic science department in the Geffen School of Medicine at UCLA. When the Department was launched just prior to the sequencing of the human genome, it was clear that the practice of genetics research would be forever changed by the infusion of massive amounts of new data. Organizing and making sense of this genomic data is one of the greatest scientific challenges ever faced by mankind. The knowledge generated will ultimately transform medicine through patient-specific treatments and prevention strategies.
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Reflecting the breadth of the field itself, the Department of Genetics consists of faculty working on diverse problems using a variety of approaches and model organisms, unified in their focus on the genome as an organizing principle for understanding biological phenomena. Genetics is not perceived simply as a subject, but rather as a way of viewing and approaching biological phenomenon. While the range of current efforts can best be appreciated by reading the research interests of individual faculty, the scope of the work conducted in the Department includes (but is by no means limited to) human genetics of both single gene disorders and complex traits, development of genomic technology, cancer biology, developmental biology, signal transduction, cell biological problems, stem cell biology, computational genetics, immunology, synthetic biology, epigenetics, evolutionary biology, and plant biology. The mission of the Department encompasses research and education while serving as a focal point for drawing together and integrating basic and clinical genetic efforts conducted across the University and its affiliated hospitals. The Department of Genetics is strongly committed to supporting its current community of faculty, postdoctoral fellows and graduate students and to securing the best new scientists, setting its sight on new research opportunities in the future.
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CellCyte Genetics acquired the patents and rights to the bioreactor unit and several other key technologies from the developer of the technology in 2006 as part of its original Intellectual property portfolio. The Company began work on remolding key parts of the bioreactor for manufacturing earlier this year as part of CellCyte's efforts to prepare for human trials and FDA application for the use of its stem cell therapies. With the manufacturing path and contract suppliers now set, CellCyte has begun gearing up this Device Division to complete development of the bioreactor and several other synergistic technologies.
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Genetics determines much (but not all) of the appearance of organisms, including humans, and possibly how they act. Environmental differences and random factors ... play a part. Monozygotic ("identical") twins, a clone resulting from the early splitting of an embryo, have the same DNA, but different personalities and fingerprints. Genetically-identical plants grown in colder climates incorporate shorter and less-saturated fatty acids to avoid stiffness.
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Genetics has revolutionized the way industries produce certain substances, many of which formerly required costly and arduous manufacturing methods. In medicine, scientists can genetically alter bacteria so that they mass-produce specific proteins, such as insulin used by people with diabetes mellitus or human growth hormone used by children who suffer from growth disorders.
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Several key concepts put forward by Mendel have been expanded, as the science of genetics has grown. It is now known that genetic information is passed on as a series of discrete units known as genes, each of which is associated with specific traits. Furthermore, most organisms (including humans) get two copies of their genetic information, one from each parent. This means that most living things have two copies of each gene, and that these two copies are not necessarily the same, since they came from different parents. When an organism reproduces, it passes only one of its two copies to an offspring. Importantly, copies of different genes separate (segregate) randomly into the next generation, which means that an offspring can receive either of the two copies that the parent has, and that the set of copies that is passed is different from offspring to offspring.
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Human Genetics