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Folic Acid: Supplements
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Supplementing with folic acid seemed to have a slightly negative effect. The researchers point out that the supplement takers had significantly more health and alcohol-related problems than did the non-takers and that the number of supplement takers was too small to draw statistically significant conclusions. They caution that the issue could be clouded by earlier findings from animal experiments that, while folic acid supplementation may be effective in preventing cancer from starting, it may actually enhance tumor development at a later stage.
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While still in the hospital... Jody learned about folic acid and began taking a vitamin supplement right away. "A few months later, I was pregnant again. On April 22, 1990, Kelsey was born. She was saved by folic acid." In 1999, Kelsey served as the March of Dimes National Ambassador; she and her parents traveled around the country to tell other families about the importance of folic acid.
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The poster entitled "Phase 1 study of the antifolate pralatrexate when given with vitamin B12 and folic acid supplementation in patients with advanced non-small cell lung cancer (NSCLC)" presented results of this Phase 1 dose ranging study. In the study, a total of 22 patients with relapsed or refractory NSCLC were treated at doses of 150 to 325 mg/m2 of PDX. The maximum tolerated dose (MTD) was determined to be 270 mg/m2, which is twice that observed in a previous Phase 1 study in which PDX was administered without vitamin supplementation. Clinically significant radiologic responses were observed. Greater than 50% of patients (13/22) received two or more prior treatment regimens. Based on PDX clinical experience to date, the Company plans to initiate a randomized Phase 2 study of PDX in patients with NSCLC.
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If you are following a low-carbohydrate diet, you may not be getting enough folic acid as well as other nutrients that are a key part of a healthy eating plan. The less carbohydrates you eat, the greater the likelihood that you need to take a vitamin supplement. Cereals, fortified grains and vegetables that are high in carbohydrates are the major sources for folic acid. Taking a vitamin and mineral supplement is recommended no matter what weight loss plan you are following. Folic acid is an essential part of your diet, so make sure you are getting enough of it, especially if you are pregnant.
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Early evidence shows that applying folic acid topically may inhibit gingival hyperplasia (overgrowth of gum tissue) secondary to phenytoin therapy. Oral folic acid supplementation has not been proven to be beneficial. More research is needed in this area.
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Supplemental folic acid can interact with anti-convulsant medications such as dilantin, phenytoin, and primidone. It ... complicates the effects of metformin (used in individuals with type 2 diabetes), sulfasalazine (used in individuals with Crohn's disease), and triamterene (a diuretic).
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