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Folic Acid: Studies
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In June, 1992, FDA re-opened its comment period on the final rules for 30 days after the agency learned that the CDC was holding another conference on folic acid. FDA held hoped that the meeting might shed new light "on the relationship between the ingestion of folic acid and neural tube defects," but it was concerned about the use of unpublished studies. FDA's mandate under NLEA required that the agency employ information available on the public docket.
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Several research groups have suggested a possible link between cleft lip and/or palate and diets low in folic acid or other vitamins in the mother. These early studies are being repeated to try and determine whether or not there really is a link and, if so, what dose of folic acid would be needed to reduce the chance of a cleft in a baby. At present there are no guidelines on this.
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Previous studies suggest folic acid may ... help prevent stroke and cardiovascular disease in adults. The Society for Maternal-Fetal Medicine recommends both men and women get into the habit of taking it.
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Numerous studies have shown that the synthetic form of folic acid helps prevent NTDs. This is why the March of Dimes, the Centers for Disease Control and Prevention (CDC), and the Institute of Medicine recommend that women who could become
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