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Folic Acid: Effects
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Title, Lawrence M., et al. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. Journal of the American College of Cardiology, Vol. 36, September 2000, pp. 758-65
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Folic acid is generally considered safe at levels of 5,000 mcg or less. Side effects are uncommon. However, large doses may cause nausea, decreased appetite, bloating, gas, decreased ability to concentrate, and insomnia. Large doses may ... decrease the effects of phenytoin (Dilantin), a seizure medication.
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Bronstrup A, Hages M, Prniz-Langenohl R, Pietrzik K. Effects of folic acid and combinations of folic acid and vitamin B12 on plasma homocysteine concentrations in healthy, young women. Am J Clin Nutr. 1998;68:1104–1110.
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Folic acid has a low acute and chronic toxicity profile. Adults receiving a daily dose of 400 mg for 5 months followed by a daily dose of 10 mg for 5 years did not present any adverse side effects.
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Folic acid is important to the field of oncology in two ways. First, prior to neoplasm formation, folic acid is important in the synthesis of DNA and RNA and the repair of damaged DNA. Second, after a tumor develops, a form of folicacid is used to counter the side effects of methotrexate and 5-fluorouracil (... called fluorouracil or 5-FU).
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