LYCOS RETRIEVER 
Flagellate
built 643 days ago
FLAGELLATE hyperpigmentation is a well-documented cutaneous complication following bleomycin sulfate therapy. Many reports describe cutaneous manifestations involving the use of bleomycin as a chemotherapeutic agent for neoplastic processes. In such instances, bleomycin is used as a systemic agent, in prolonged treatments, and in doses usually greater than 100 U. The mechanism for flagellate hyperpigmentation following bleomycin is unknown. Proposed mechanisms for this observed adverse effect include localized increases in melanogenesis, pigmentary incontinence secondary to inflammation, alterations in normal pigmentation patterns, and induction of neutrophilic eccrine hidradenitis.
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Flagellate