LYCOS RETRIEVER 
Fibroids: Size
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For premenopausal women with fibroids and Natural Progesterone use, the fibroids disappear, remain the same size, or rarely get bigger. The fibroids that rarely get bigger do so because of xenoestrogens (foreign chemical estrogens). This is usually accompanied by an increased of soreness of breasts. Chronic exposure to xenoestrogens desensitizes the body to estrogen. In other words, the body tries to get used to too much estrogen, by becoming less sensitive to estrogen. When Natural Progesterone is taken, the body resensitizes the estrogen sensitivty back to normal, and it appears as though the patient is getting more estrogen even though estrogen exposure is NOT increased.
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One group of drugs aimed at reducing the size of fibroids are called gonadotrophin releasing hormone analogues (GnRH analogues). These drugs stop the ovaries from producing hormones. Their effect is sometimes described as a "medical menopause" and they can cause menopausal symptoms such as hot flushes. However, there are increased risks of harmful side–effects such as osteoporosis (thinning of the bones) if they are given for more than six months. They may be used to control symptoms in women who are close to the menopause for whom symptoms may soon be about to improve anyway.
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Depending on the size and placement of the fibroids, myomectomy can be an outpatient surgery or require two to three days in the hospital. However, myomectomy is usually major surgery that involves cutting out the biggest fibroid or collection of fibroids and then stitching the uterus back together. Most women have multiple fibroids and it is not physically possible to remove all of them because it would remove too much of the uterus. While myomectomy is frequently successful in controlling symptoms, the more fibroids the patient has, generally, the less successful the surgery. In addition, fibroids may grow back several years later.
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The size of fibroids can vary from as small as a pea to that of a melon. At least one in five women develop a fibroid at some stage of their life, usually between the ages of 30-50 years old. Fibroids are more common in women who are overweight and women of Afro-Caribbean origin.
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Cancerous fibroids are rare. The trouble they cause varies by individual, but is mostly a function of their size and rate of growth. The most typical symptom of fibroids is heavy or irregular bleeding. The blood vessels that feed the fibroid become altered or engorged, rather like varicose veins. This area then bleeds more than other areas of the uterus, heavier at menses and sometimes in between menses.
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Gonadotropin-releasing hormone (GnRH) agonists are the most common medical treatment for fibroids. Leuprolide (Lupron Depot®) is an example of a GnRH agonist. Most women who use GnRH agonists temporarily stop having menstrual periods and have a significant reduction in the size of their fibroid(s). Reducing or eliminating menstrual bleeding can improve anemia.
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