LYCOS RETRIEVER 
Fibroids: Estrogens
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Fibroids are almost unknown before an adolescent starts having menstrual periods. They grow slowly unless they are under the stimulation of extra estrogen and progesterone such as oral contraceptives. After menopause, the fibroids and entire uterus get smaller unless hormone replacement therapy is given
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GnRH agonists are a class of medications that temporarily shrinks fibroids and stops heavy bleeding by blocking production of the female hormone, estrogen. Lupron is the most well known of these drugs. Although Lupron can improve fibroid symptoms, it causes unpleasant, menopausal symptoms such as hot flashes and with long-term use, leads to bone loss.
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Lupron Depot® (3.75 mg and - 3 Month 11.25 mg), in combination with iron, is used for the preoperative treatment of anemia associated with uterine fibroids. Most common side effects with Lupron Depot are generally those related to low estrogen levels, including hot flashes, headaches, and vaginal dryness. A small amount of bone loss (average 2.7% at month three) may ... occur during therapy.
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The fact that fibroids seemingly are estrogen-dependent has led to attempts to control them by reduction in available estrogen. Hormone-like agents that counter the action of gonadotropin-releasing hormone (GnRH) are being investigated as one such agent. The use of a GnRH agonist lowers blood levels of estrogen and reduces uterine volume by as much as 60 percent.
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Weight loss can be important in treating fibroids. Body fat is a secondary production site for estrogen, so excess weight contributes to estrogen-progesterone imbalance. However, caution is required when dieting, as low–fat diets actually sabotage hormonal balance.
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Doctors are not sure what causes fibroids. But the female hormones estrogen and progesterone seem to make them grow. Your body makes the highest levels of these hormones during the years when you have periods.
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