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Erythromycin: Bacteria
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Erythromycin is an antibiotic that is used to treat a wide range of medical ailments from acne to sexually transmitted diseases. Erythromycin inhibits the propagation of proteins in bacterial cells. The streptococcus strain of bacteria is susceptible to erythromycin, but staphylococcus strains of bacteria have become particularly resistant to erythromycin. Erythromycin has ... been associated with several prenatal defects such as pyloric stenosis, a constriction of the passage between the stomach and small intestine.
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Erythromycin is a macrolide antibiotic used to treat a wide variety of bacterial infections. Several chemical forms of erythromycin are available for oral use to treat infections in the body. Erythromycin-containing products are ... available to treat eye and skin infections.
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Erythromycin may possess bacteriocidal activity, particularly at higher concentrations[1]. The mechanism is not fully elucidated .... By binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently strucutre/function processes critical for life or replication are inhibited[2]. Erythromycin interferes with aminoacyl translocation, preventing the transfer of the tRNA bound at the A site of the rRNA complex to the P site of the rRNA complex. Without this translocation, the A site remains occupied and thus the addition of an incoming tRNA and its attached amino acid to the nascent polypeptide chain is inhibited. This interferes with the production of functionally useful proteins and is therefore the basis of antimicrobial action.
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Erythromycin works by blocking the bacterial cell's machinery for making new proteins. Since proteins both make up much of the cell's structure and make the enzymes that direct all the cell's chemical reactions, blocking protein manufacturing makes the cell unable to function. Erythromycin in low doses will stop bacteria from growing and multiplying, but you need a higher concentration to kill the bacteria. However, if you can stop growth until your immune system kicks in, that will help you get rid of the infection.
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Erythromycin is used in both dogs and cats to treat bacterial infections, including skin infections, wound infections, bone infections, pneumonia and sinus infections. It ... has been used for some tick-borne infections, such as Lyme disease.
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Erythromycin prevents bacteria from growing, by interfering with their protein synthesis. Erythromycin binds to the 23s rRNA molecule in the 50S of the bacterial ribosome, blocking the exit of the growing peptide chain ... inhibiting the translocation of peptides.
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