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Endometriosis: Women
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Endometriosis is a common problem. It occurs in an estimated 10% of women during their reproductive years. The prevalence may be as high as 35% among infertile women. Although endometriosis is typically diagnosed between the ages of 25 and 35, the problem probably begins about the time that regular menstruation begins.
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Endometriosis is an abnormal growth of the endometrium and associated with many symptoms with the most prevalent being pelvic pain and infertility. Contrary to most of the current treatments for endometriosis, cetrorelix is not associated with menopause-like side-effects such as hot-flashes and fatigue. Endometriosis affects between 10% to 20% of women of child-bearing age which represents approximately 26 million women. According to Datamonitor, in 2004, endometriosis treatments represented a US$1 billion to US$1.5 billion market.
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SUMMARY: Endometriosis occurs in women after menarche and usually involves severe abdominal pain due to bleeding and tissue sloughing from endometrial cysts in the pelvic cavity. Modern treatments include surgical removal of the cysts and hormonal blockage, but these therapies are often not satisfactory. In China, endometriosis is sometimes treated with the herbal drug gossypol, claimed to be superior to Danazol, but which has too many side effects to be used in the West as an herb therapy. Complex, non-toxic herb formulas are ... used in China and these could be used world-wide. Most of those formulas involve treatment of a blood-stasis syndrome, often with a combination of herbs (e.g., rhubarb, typha, salvia) and animal substances (e.g., turtle shell, leech). The Chinese researchers report a significant success rate in alleviating endometriosis symptoms when using these formulas.
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Endometriosis affects women of childbearing age in the United States. It affects anywhere from 7 to 15% of women between the ages of 25 to 44, but can ... occur in teenagers. Endometriosis can run in families. A woman whose direct female relatives (mother or sister) have endometriosis is more likely to also have the disease. Women who have had their first pregnancy after the age of 30, those with an abnormally shaped uterus, and those with menstrual periods that last longer than one week with an interval of less than 27 days between are more likely to have endometriosis.
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Endometriosis was once called the "career woman's disease" because it was thought to be a product of delayed childbearing. The statistics defy such a narrow generalization; ... pregnancy may slow the progress of the condition. A more important predictor of a woman's risk is if her female relatives have endometriosis. Another influencing factor is the length of a woman's menstrual cycle. Women whose periods last longer than a week with an interval of less than 27 days between them seem to be more prone to the condition.
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Endometriosis is considered one of the three major causes of female infertility. It has been estimated that between 25 and 50 percent of all infertile women have endometriosis. In mild to moderate cases, the infertility may be just temporary with surgery to remove adhesions, cysts, and scar tissue restoring fertility. In other cases (a very small percentage), women may remain infertile. Physicians are still not clear how endometriosis affects fertility.
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