LYCOS RETRIEVER 
Effexor: Effexor Xr
built 630 days ago
During its premarketing assessment, multiple doses of Effexor XR were administered to 705 patients in Phase 3 major depressive disorder studies and Effexor was administered to 96 patients. During its premarketing assessment, multiple doses of Effexor XR were ... administered to 1381 patients in Phase 3 GAD studies, 819 patients in Phase 3 Social Anxiety Disorder studies, and 1314 patients in Phase 3 panic disorder studies. In addition, in premarketing assessment of Effexor, multiple doses were administered to 2897 patients in Phase 2 to Phase 3 studies for major depressive disorder. The conditions and duration of exposure to venlafaxine in both development programs varied greatly, and included (in overlapping categories) open and double-blind studies, uncontrolled and controlled studies, inpatient (Effexor only) and outpatient studies, fixed-dose, and titration studies. Untoward events associated with this exposure were recorded by clinical investigators using terminology of their own choosing. Consequently, it is not possible to provide a meaningful estimate of the proportion of individuals experiencing adverse events without first grouping similar types of untoward events into a smaller number of standardized event categories.
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The recommended starting dose for Effexor is 75 mg/day, administered in two or three divided doses, taken with food. Following evaluation of tolerance and effect on symptoms, the dose may be increased to 150 mg/day and then to 225 mg/day. Increments in dosage should be restricted only to 75 mg/day and should be made at intervals of at least 4 days each. Effexor XR should be administered in a single dose with food either in the morning or in the evening at approximately the same time each day.
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For some patients seeking relief from frequent tension headaches, the antidepressant Effexor XR may reduce the number of days with headache. Dr. N. P. Zissis, at Wyeth Hellas in Athens, recruited patients with tension headaches that occurred more often than on five days per month. The 60 participants were randomly assigned to Effexor XR or an inactive placebo. They could ... take aspirin or paracetamol / acetaminophen but no other pain killers. At the end of the 12-week trial, the average reduction in the numbers of days with headache was significantly greater in the Effoxor XR group (45 percent) compared with the placebo group (16 percent). Cephalalgia, April 2007.
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Before starting Effexor XR, tell your doctor about any medicines you're taking, including over-the-counter drugs and herbal supplements. If you take MAOIs you should not take Effexor XR. If you are taking antidepressants you should be watched closely for signs that your condition is getting worse or that you are becoming suicidal, especially when you first start therapy, or when your dose is increased or decreased. You should ... be watched for becoming agitated, irritable, hostile, impulsive, or restless. Such symptoms should be reported to your doctor right away. Effexor XR may raise blood pressure in some patients, so blood pressure should be monitored regularly.
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Effexor XR, which is generically prescribed as venlafaxine, is commonly used to treat depression, anxiety, and panic disorders. Effexor XR is part of the family of antidepressants known as SSNRIs, or selective serotonin norepinphrine reuptake inhibitors. SSNRIs help to balance the chemicals in the brain believed to cause depression, anxiety disorders, and panic disorders.
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Effexor (venlafaxine) is used to treat depression. Effexor XR (venlafaxine hydrochloride; extended release capsules) is used to treat depression, generalized anxiety disorder (GAD), and social anxiety disorder (SAD). Effexor is made by Wyeth Pharmaceuticals, Inc. and was approved by the U.S. Food and Drug Administration (FDA) in 1993.
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Effexor Xr