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Ebola: Humans
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Ebola is extremely destructive to the host, which could probably explain the fact why it has not yet been as successful in penetrating the human species as AIDS. The extreme speed at which it spreads through the body and destroys it, prevents it from transmitting itself from host to host with a high rate of success. While AIDS is a silent stalker, Ebola is a violent, bloody predator.
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Ebola viruses are found in Central Africa. The source of the viruses in nature remains unknown. Monkeys, like humans, appear to be susceptible to infection and might serve as a source of virus if infected.
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On the African continent, Ebola infections of human cases have been linked to direct contact with gorillas, chimpanzees, monkeys, forest antelope and porcupines found dead in the rainforest. So far, the Ebola virus has been detected in the wild in carcasses of chimpanzees (in Côte-d’Ivoire and Republic of Congo), gorillas (Gabon and Republic of Congo) and duikers (Republic of Congo).
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Four laboratory workers in Russia who had possible Ebola exposure were treated with a combination of a goat-derived anti-Ebola immunoglobulin plus recombinant human alpha-2 interferon. One of these patients had a high-risk exposure and developed clinical evidence of Ebola infection. All 4 patients recovered. Equine IgG containing high-titer neutralizing antibodies to Ebola protected guinea pigs and baboons but was not effective in protecting infected rhesus monkeys.
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Much remains unknown about Ebola hemorrhagic fever. Experts still do not know its exact origin or its natural habitat. However, it is believed to be transmitted by animals (possibly bats), and cases of the illness in humans have been confirmed in the Democratic Republic of the Congo, Gabon, Sudan, the Ivory Coast and Uganda.
Vector. The natural reservoir for Ebola is unknown. Epidemiologists have tested bats, monkeys, spiders and ticks for the virus, but have not been able to acquire definitive data. Common factors indicate that the natural reservoir is part of rural Africa, and CDC tests have shown that 10% of all Asian and African monkeys have antibodies to filoviruses. However, because the virus is as pathogenic in nonhuman primates as it is in humans, it is highly unlikely that monkeys themselves are areservoir. It is speculated that persistent mammalian infection may help maintain the virus in nature, but that the natural reservoir is more likely tobe a long-lived arthropod associated with the monkeys.
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