LYCOS RETRIEVER 
Doxycycline: Doses
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The standard dose of oral Doxycycline is 200 milligrams on the first day of treatment (100 milligrams every 12 hours) followed by a maintenance dose of 100 milligrams per day. The maintenance dose may be taken as a single dose or as 50 milligrams every 12 hours.
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The Doxycycline is absorbed quickly and almost fully (up to 90 - 100% of the dosage taken) in the gastrointestinal tract. Its admission during meals does not affect considerably the absorption. Because of the calcium contained, the dairy products considerably decrease the absorption of Doxycycline, since they lead to building of Xelate complexes, difficult for absorption. After a peroral admission of Doxycycline of a dosage of 200 mg maximum concentrations of plasma are followed, 2-4 Mg/ml from the 2nd to the 4th hour and 24 hours after the admission the plasma concentration is about 1 Mg/ml. The duration of the plasma half-life of the Doxycycline is from 15 to 22 hours; it does not change considerably if kidney function is disturbed. It connects to the plasma proteins from 85 to 96%, it penetrates well into the fabrics and fluids of the system.
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Doxycycline is indicated for the prophylaxis of malaria due to Plasmodium falciparum in short-term travelers ( < 4 months) to areas with chloroquine and/or pyrimethamine- sulfadoxine resistant strains. See DOSAGE AND ADMINISTRATION section and Information for Patients subsections of the PRECAUTIONS section.
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Doxycycline is normally administered by mouth as doxycycline or its various derivatives. Doses are expressed in terms of doxycycline. The usual dose is 200 mg of doxycycline on the first day (as a single dose or 100 mg repeated after 12 hours), followed by 100 mg daily.
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The Doxycycline may provoke nausea, emesis, and diarrhea. Continuous use and in higher dosages may cause ulcer of the mucosa of the esophagus, glossitis, oral Candida. In rare cases there are damages of the liver and transitory changes in the hematologic indices. The Doxycycline may provoke photosensibility. Cutaneous hypersensitive reactions have been watched and, more rarely, other heavy manifestations of hypersensitivity: (anaohy-laxis, edema of Quinke etc.)
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Doxycycline may enhance the activity of warfarin (Coumadin) and cause excessive "thinning" of the blood leading to exaggerated bleeding, necessitating a reduction in the dose of warfarin. Phenytoin (Dilantin), carbamazepine (Tegretol), and barbiturates (such as phenobarbital) may enhance the metabolism (destruction) of doxycycline ... making it less effective.
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