LYCOS RETRIEVER 
Diclofenac: Swelling
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Diclofenac enters the synovial fluid, where the maximum concentrations will be measured 2 to 4 hours after peak plasma levels are reached. Two hours after reaching peak plasma levels, the concentration of diclofenac will be higher in the synovial fluid than in the plasma. The terminal half-life for diclfenac in plasma is 1 to 2 hours, while the half-life for the elimination from the synovial fluid is 3 to 6 hours.
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Clinical studies, as well as post-marketing observations, have shown that Diclofenac Potassium can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure (see PRECAUTIONS: Renal Effects), as well as to assure diuretic efficacy.
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Diclofenac Potassium tablets are contraindicated in patients with known hypersensitivity to diclofenac. Diclofenac Potassium should not be given to patients who have experienced asthma, urticaria, or allergic type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients (see WARNINGS: Anaphylactoid Reactions, and PRECAUTIONS: General: Preexisting Asthma).
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Diclofenac diffuses into and out of the synovial fluid. Diffusion into the joint occurs during the first 4 hours following a dose, while plasma levels are higher than those in synovial fluid, after which the process reverses and synovial fluid levels are slightly higher than plasma levels. It is not known whether diffusion into the joint plays a role in the effectiveness of Diclofenac.
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