LYCOS RETRIEVER 
Diclofenac: Swelling
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Diclofenac, as the potassium salt, is a faintly yellowish white to light beige, virtually odorless, slightly hygroscopic crystalline powder. It is freely soluble in methanol, soluble in ethanol, and practically insoluble in chloroform and in dilute acid. Diclofenac Potassium is soluble in water. The n-octanol/water partition coefficient is 13.4 at pH 7.4 and 1545 at pH 5.2. It has a single dissociation constant (pKa) of 4.0 ± 0.2 at 25°C in water.
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Diclofenac may ... be a unique member of the NSAIDs. There is some evidence that diclofenac inhibits the lipooxygenase pathways, thus reducing formation of the leukotrienes (also pro-inflammatory autacoids). There is also speculation that diclofenac may inhibit phospholipase A2 as part of its mechanism of action. These additional actions may explain the high potency of diclofenac - it is the most potent NSAID on a broad basis.
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How it should be taken :Diclofenac comes in the form of coated tablets. They should be swallowed whole; do not crush or break them. Your prescription label tells you how much to take at each dose. Ask your pharmacist any questions you have about refilling your prescription.
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Diclofenac may reduce the removal of the following medicines from the body and so may increase the blood levels and risk of side effects of these medicines. People taking diclofenac with any of these should be closely monitored by their doctor:
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Diclofenac is ... used to treat cancer by killing cancer cells. When applied to the skin, diclofenac may be used to treat actinic keratosis, a skin problem that may be cancer or may become cancerous if not treated. The exact way that topical diclofenac helps this condition is unknown.
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When Diclofenac Potassium is administered with aspirin, its protein binding is reduced. The clinical significance of this interaction is not known; ... as with other NSAIDs, concomitant administration of diclofenac and aspirin is not generally recommended because of the potential of increased adverse effects.
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