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Diclofenac: Diclofenac Sodium
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Diclofenac sodium is a phenylacetic acid derivative that is a white to off-white, virtually odorless, crystalline powder. Diclofenac sodium is freely soluble in methanol, soluble in ethanol and practically insoluble in chloroform and in dilute acid. Diclofenac sodium is sparingly soluble in water. Its chemical formula and name are:
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Diclofenac sodium is a faintly yellow-white to light beige, virtually odorless, slightly hygroscopic crystalline powder. It is freely soluble in methanol, sparingly soluble in water, very slightly soluble in acetonitrile, and insoluble in chloroform and in 0.1N hydrochloric acid. Its molecular weight is 318.14. In water, diclofenac sodium has a single dissociation constant (pKa) of 4.0.
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Diclofenac sodium is contra-indicated in patients with known hypersensitivity to diclofenac and in patients who respond to aspirin and aspirin-type drugs with sensitivity reactions like asthma, acute rhinitis and urticaria. Diclofenac sodium is absolutely contra-indicated in patients with peptic ulceration or a history of such ulceration, and should be used with caution in patients with renal or hepatic insufficiency.
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Diclofenac sodium is a nonsteroidal antiinflammatory drug (NSAID) that has been used in 120 countries since its introduction in Japan in 1974. It is currently the eighth largest-selling drug and the most frequently used NSAID in the world. Diclofenac, a phenylacetic acid derivative, is a potent inhibitor of cyclooxygenase enzyme activity, and may ... interact with the lipoxygenase enzyme pathway, and with the release and reuptake of arachidonic acid. Diclofenac is almost completely absorbed, highly protein-bound, penetrates well into synovial fluid, and is extensively metabolized.
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MedStore International gives customers the option to either buy Voltaren or buy Diclofenac Sodium medication at lower prices. We research the price of Voltaren and generic Diclofenac Sodium, we verify the source and the quality of both the Voltaren and Diclofenac Sodium medication available, we organize a registered pharmacy in to fill orders for Voltaren and Diclofenac Sodium medication, and we pass savings on to you the customer.
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Diclofenac Sodium