LYCOS RETRIEVER
Dexamethasone: Vomiting
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Dexamethasone-21-isonicotinate is an esterified form of dexamethasone that is approved and marketed for horses. Work in laboratory animals has shown it to be more powerful and longer acting than the parent compound. Multiple laboratory tests on different species have shown significantly increased anti-inflammatory activity and duration of response, without increases in catabolic effects or adverse effects on electrolyte metabolism.
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Dexamethasone enhances REDD1 protein expression in skeletal muscle and L6 myoblasts. A, fasted rats ([C]ontrol) were injected with dexamethasone, and 1,000 x g supernatants were subjected to protein immunoblot analysis as described under "Experimental Procedures." The inset depicts the results of a typical blot for control (C) and dexamethasone-treated (D) rats. The results represent the mean ± S.E. of five animals for each group. B, L6 myoblasts were deprived of serum for 18 h and then exposed to 1 µM dexamethasone or vehicle for 4 h prior to harvest as described under "Experimental Procedures."
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Dexamethasone is a synthetic glucocorticoid devoid of mineralocorticoid effects. Glucocorticoids are cytotoxic to leukemia, myeloma, and lymphoma cells, probably via induction of apoptosis. Dexamethasone does not appear to be cell-cycle phase specific.2
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Dexamethasone has been shown to improve pulmonary function in some infants with bronchopulmonary dysplasia. The mechanisms of its action are not clear and the complications associated with its use are significant. The most important complication is infection. Still, for some infants, use of this agent may allow more rapid withdrawal of mechanical ventilatory support.
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Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid hormones. It acts as an anti-inflammatory and immunosuppressant. Its potency is about 20-30 times that of hydrocortisone and 4-5 times of prednisone.
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