LYCOS RETRIEVER 
Dexamethasone: Treatment
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Dexamethasone is a synthetic steroid that is chemically related to the natural hormones secreted by the adrenal cortex. The drug suppresses acute and chronic inflammation, potentiates the relaxation of vascular smooth muscle by beta-adrenergic agonists, and possibly alters airway hyper-reactivity. In emergency care, dexamethasone is generally used in the treatment of allergic reactions, asthma, spinal cord injury and occasionally the management of shock.
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Dexamethasone treatment increased significantly the serum glucose levels (p = 0.009) [Fig 6 ]. During sternum closure, the values reached peak values of 10.7 ± 0.6 mmol/L in the dexamethasone group and 7.4 ± 0.5 mmol/L in the placebo group. The glucose values in the dexamethasone group were significantly higher than in the placebo group during sternum closure (p = 0.005), at 6-h ICU (p = 0.007), and at 24-h ICU (p = 0.023).
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Dexamethasone is used systemically in high doses in emergency situations for anaphylactic reactions, spinal chord trauma, or shock. It is used in the management and treatment of immune mediated disease such as immune mediated hemolytic anemia, or thombocytopenia: some cancers: allergic reactions such as asthma, hives, and itching: inflammatory diseases and some neurologic diseases. Dexamethasone is ... used topically in the treatment of a variety skin and eye problems.
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Dexamethasone is used as treatment for a variety of neonatal syndromes, including respiratory distress. The present study utilized the power of comprehensive lipid profiling to characterize changes in lipid metabolism in the neonatal lung and brain associated with dexamethasone treatment and ... determined the interaction of dexamethasone with hypoxia. A 4-day tapering-dose regimen of dexamethasone was administered at 0800 on postnatal days 3 (0.5 mg/kg), 4 (0.25 mg/kg), 5 (0.125 mg/kg), and 6 (0.05 mg/kg). A subgroup of rats was exposed to hypoxia from birth to 7 days of age. Dexamethasone treatment elicited numerous specific changes in the lipid profile of the normoxic lung, such as increased concentrations of saturated fatty acids in the phosphatidylcholine and cholesterol ester classes. These increases were more profound in the lungs of hypoxic pups.
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Dexamethasone is indicated for the treatment of acute musculoskeletal inflammations, such as bursitis, carpitis, osselets, tendonitis, myositis, and sprains. If boney changes exist in any of these conditions, joints, or accessory structures, responses to dexamethasone cannot be expected. In addition, dexamethasone may be used as supportive therapy in fatigue, heat exhaustion, influenza, laminitis, and retained placenta provided that the primary cause is determined and corrected.
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Dexamethasone 21 isoniconate is generally used as an anti-inflammatory drug in the treatment of musculoskeletal problems. It should not be used to the exclusion of other forms of therapy and it should not be used in conditions requiring prolonged therapy. Dexamethasone 21 isoniconate is given by intra-muscular injection.
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