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Dermatitis: Atopic
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A number of studies have shown that foods may trigger or worsen atopic dermatitis in some people, particularly infants and children. In general, the worse the atopic dermatitis and the younger the child, the more likely food allergy is present. An allergic reaction to food can cause skin inflammation (generally an itchy red rash), gastrointestinal symptoms (abdominal pain, vomiting, diarrhea), and/or upper respiratory tract symptoms (congestion, sneezing, and wheezing). The most common allergenic (allergy-causing) foods are eggs, milk, peanuts, wheat, soy, and fish. A recent analysis of a large number of studies on allergies and breastfeeding indicated that breastfeeding an infant for at least 4 months may protect the child from developing allergies. However, some studies suggest that mothers with a family history of atopic diseases should avoid eating common allergenic foods during late pregnancy and breastfeeding.
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A: Food allergies have been linked to atopic dermatitis in only about 10 percent to 15 percent of cases. The most common sensitivities are to eggs, milk, soy, wheat, nuts, and fish. If you suspect a food allergy, your pediatrician or dermatologist can help you eliminate various items from your child's diet to confirm your suspicion. Allergy tests are infrequently done.
The original RFP-2 contract, awarded in 2004 by NIAID, included a Phase II study with IMVAMUNE in persons diagnosed with atopic dermatitis. However the need for more clinical safety data in this population has increased due to requirements from the Food and Drug Administration (FDA) to generate data to support an Emergency Use Authorization (EUA) for IMVAMUNE.
A person with eczema often has a history of allergic manifestations such as asthma or hay fever, or a family history of asthma, hay fever, or atopic dermatitis. Eczema may be set off by extreme temperatures, stress, sweating, medication, clothing (especially wool or silk), grease, oils, soap and detergents, and environmental allergens. Patients with eczema are ... very susceptible to severe infections from certain viruses, for example, the herpes simplex virus that produces fever blisters and sores.
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Atopic dermatitis may ... affect the skin around the eyes, the eyelids, and the eyebrows and lashes. Scratching and rubbing the eye area can cause the skin to redden and swell. Some people with atopic dermatitis develop an extra fold of skin under their eyes. Patchy loss of eyebrows and eyelashes may also result from scratching or rubbing.
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Atopic dermatitis affects more than 15 million patients, resulting in skin rash, redness, swelling, crusting, and scaling. The disease affects nearly 20% of infants and young children, some of which continue to experience symptoms as adults. The exact cause of atopic dermatitis is unknown; ... genetics and environmental factors are considered key factors. Topical corticosteroids are the gold standard of treatment for atopic dermatitis, with more than $1 billion in prescriptions written annually by US physicians for inflammatory dermatoses.
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