LYCOS RETRIEVER 
Cystitis: Findings
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Cystitis ... may be cause by chemicals and medications. Both intravenous and oral cyclophosphamide, used to treat malignancies and vasculitides (eg, SLE, Wegener granulomatosis) can cause hemorrhagic cystitis. Low-dose methotrexate, used to treat rheumatoid arthritis, also has been reported to cause hemorrhagic cystitis.
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The pathophysiology of chronic idiopathic cystitis appears to involve complex interactions between multiple body systems. Abnormalities have been found in the bladder, nervous system, hypothalamic-pituitary-adrenal axis, and other body systems in cats with idiopathic cystitis. Histological changes, urothelial abnormalities, and decreased excretion of both total urinary GAG and a specific GAG, GP-51, have been identified in the bladders of cats with idiopathic cystitis. Histological changes generally are nonspecific, and may include an intact or damaged urothelium with submucosal edema, dilation of submucosal blood vessels with marginated neutrophils, submucosal hemorrhage, and sometimes increased mast cell infiltration. There is a paucity of neutrophilic infiltration, but there may be a minor increase in lymphoplasmacytic cells in the submucosa.
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Mesnex® (mesna) tablets, 400 mg Indication: use as a prophylactic agent in reducing the incidence of ifosfamide-induced hemorrhagic cystitis. Mesnex tablets are given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage (w/w) at the time of ifosfamide administration. The total daily dose of mesna is 100% of the ifosfamide dose. Mesnex injection originally approved in 1988; 400-mg tablets approved in March 2001. Dosage forms: tablets, 400 mg tablets; multidose vial, 100 mg/mL.
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For some women cystitis is a rare event, for others it happens four or five times a year. Cystitis is more common in sexually active women, during pregnancy and after the menopause.
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The diagnosis of cystitis due to radiation therapy, chemicals, or autoimmune disease can be established in part by obtaining the relevant history. In subjects with radiation cystitis, associated UTIs are not uncommon. Cystoscopy may be required to eliminate other causes of bleeding such as recurrent tumor, a new primary tumor, or clot retention.
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Combining corn silk with couchgrass, bearberry or even yarrow is good for treating cystitis. You may need to experiment to see what works for you. Corn silk is used as a remedy for cystitis, stones, bladder irritation, edema, and gonorrhea. Its herbal medicinal qualities are diuretic, demulcent, anti-inflammatory, tonic, anodyne, alterative, and lithotriptic. It is really a “soother”.
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