LYCOS RETRIEVER 
Cystitis: Cats
built 607 days ago
Abnormalities in the hypothalamic-pituitary-adrenal axis (HPA) ... have been observed in cats with idiopathic cystitis. Increased concentrations of corticotropin releasing factor (CRF) from the hypothalamus and ACTH from the anterior pituitary gland have been identified at times of decreased serum cortisol response to ACTH stimulation during periods of stress in cats with idiopathic cystitis, documenting the presence of reduced adrenocortical reserve in this population. CRF stimulates both the release of ACTH from the anterior pituitary and activation of the sympathetic nervous system in the brainstem. During chronic stress in cats with idiopathic cystitis, there appears to be a disproportionate activation of noradrenergic outflow in the absence of a parallel increase in outpouring of adrenocortical steroids (ACS). This phenomenon may be important since cortisol and other ACS normally restrain sympathetic nervous system outflow, and also inhibit their own release by feedback inhibition at the level of the anterior pituitary and hypothalamus to terminate the stress response. Decreased ACS activity may adversely affect epithelial permeability, as cortisol is known to enhance tight junction integrity to reduce permeability in other tissues.
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After one episode of cystitis, a cat is predisposed to recurrence. This is due to both systemic and environmental factors. This is the primary reason that an appropriate diet should be fed in the future.
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Many cats have recurrence of cystitis. This is one reason that a virus is suspected as the cause. It is ... the reason that a proper diet should be fed in the future.
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