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Cystic Fibrosis: United States
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Cystic Fibrosis (CF) is the most common lethal genetic disorder in the United States and there is no cure. It affects children and young adults causing chronic infections. If you would like to help find a cure or learn more about CF you can contact the following sources:
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Cystic Fibrosis, or CF as it is commonly called, is a disease caused by an inherited genetic defect. About 1 in 23 people in the United States carry at least one defective gene, which makes it the most common genetic defect of its severity in the United States. People with Cystic Fibrosis suffer from chronic lung problems and digestive disorders.
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Cystic fibrosis may be diagnosed by many different categories of testing including those such as, newborn screening, sweat testing, or genetic testing. As of 2006 in the United States, 10percent of cases are diagnosed shortly after birth as part of newborn screening programs. The newborn screen initially measures for raised blood concentration of immunoreactive trypsinogen.[19] However, most states and countries do not screen for CF routinely at birth. Therefore, most individuals are diagnosed after symptoms prompt an evaluation for cystic fibrosis. The most commonly-used form of testing is the sweat test. Sweat-testing involves application of a medication that stimulates sweating (pilocarpine) to one electrode of an apparatus and running electric current to a separate electrode on the skin.
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Cystic fibrosis is a common genetic disease within the Caucasian (white) population in the United States. The disease occurs in 1 in 2,500 to 3,500 Caucasian newborns. Cystic fibrosis is less common in other ethnic groups, affecting about 1 in 17,000 African Americans and 1 in 31,000 Asian Americans.
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Cystic fibrosis is the most common inherited disease leading to a shortened life span among white people in the United States. It occurs in about 1 of 3,300 white infants and in 1 of 15,300 black infants. It is rare in Asians. Cystic fibrosis is equally common in boys and girls.
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Cystic fibrosis affects more than 30,000 children and young adults in the United States. It can be mild or severe, depending on the person. To make normal mucus, the body needs a special protein. This protein is defective in cystic fibrosis, producing the thick, sticky mucus that causes problems for people with CF.
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