LYCOS RETRIEVER 
Cordarone
built 633 days ago
Consistent with the slow rate of elimination, antiarrhythmic effects persist for weeks or months after Cordarone is discontinued, but the time of recurrence is variable and unpredictable. In general, when the drug is resumed after recurrence of the arrhythmia, control is established relatively rapidly compared to the initial response, presumably because tissue stores were not wholly depleted at the time of recurrence.
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Because Pacerone and Cordarone have been linked to serious adverse reactions, only authorized physicians experienced in the treatment of heart arrhythmia should administer the drugs. Serious reactions to Amiodarone Hydrochloride include: pulmonary toxicity, sometimes fatal, abnormal liver function tests, hypothyroidism and optic neuropathy leading to blindness in some cases. Because of these potentially dangerous side effects, users are often forced to reduce their dosage or discontinue treatment of the drug.
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Following oral administration in man, Cordarone is slowly and variably absorbed. The bioavailability of Cordarone is approximately 50%, but has varied between 35 and 65% in various studies. Maximum plasma concentrations are attained 3 to 7 hours after a single dose. Despite this, the onset of action may occur in 2 to 3 days, but more commonly takes 1to3weeks, even with loading doses. Plasma concentrations with chronic dosing at 100to600mg/day are approximately dose proportional, with a mean 0.5mg/L increase for each 100mg/day. These means... include considerable individual variability.
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Cordarone may cause dizziness, lightheadedness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Cordarone . Using Cordarone alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
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Do not use Cordarone X if you are pregnant or are thinking of getting pregnant. Cordarone X is best avoided in the 3 months before getting pregnant and during pregnancy. This is because it can stay in the body for several months even after you stop taking it.
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