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Clozaril
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Clozaril is an Atypical Antipsychotic drug used to treat schizophrenia. Clozaril (Generic: Clozapine) was approved by the FDA on April 28, 1997 is manufactured by Novartis Pharmaceuticals. Clozaril has been linked with diabetes, hyperglycemia and pancreatitis. These findings, from researchers at Duke University and the Food & Drug Administration appear in the January 2005 issue of the Journal of the American Medical Association (JAMA).
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Clozaril has effects on the immune system. People who take Clozaril are prone to getting infections. You will need to have regular blood tests while you are taking Clozaril to see if it is having an affect on your immune system. When you first start taking Clozaril you will have to go for a blood test every week. After a while you will probably need to have fewer blood tests. For information on having blood tests while you are taking Clozaril speak to your prescriber or a member of your medical team.
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Mr. A was a 79-year-old man with a history of paranoid schizophrenia who was treated as an outpatient with Clozaril (Novartis Pharmaceuticals), 200 mg in the morning and 300 mg at bedtime. Mr. A’s psychosis had been stable with this dose for more than 4 years. During one visit, Clozaril was switched inadvertently to generic clozapine (Mylan Pharmaceuticals). One month later, Mr. A was admitted to the hospital with increasing paranoid delusions of being poisoned as well as failure to thrive after refusing to take anything by mouth for several days. Other causes for his altered mental status were ruled out, and it was concluded that Mr. A’s symptoms were due to an exacerbation of his schizophrenia. Mr. A was discharged 3 days later with the same dose of generic clozapine.
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In very rare cases, Clozaril has been known to cause a potentially fatal inflammation of the heart. This problem is most likely to surface during the first month of treatment, but has ... occurred later. Warning signs include unexplained fatigue, shortness of breath, fever, chest pain, and a rapid or pounding heartbeat. If you develop these symptoms, see your doctor immediately. Even a suspicion of heart inflammation warrants discontinuation of Clozaril.
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Clozaril is considered the gold standard because it is the most successful antipsychotic medication for people with schizophrenia who have not responded well to other medications. Clozaril is unique medication which treats positive symptoms such as hallucinations, delusions, and bizarre behavior and hostility. It ... treats negative symptoms such as blunted emotions, lack of motivation and inability to experience pleasure. All the other antipsychotic medications are compared to Clozaril, giving the medication the name of the gold standard.
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Clozaril