LYCOS RETRIEVER 
Clonidine: Patients
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Clonidine should be used only with caution and close physician supervision in patients with chronic renal failure, coronary artery disease, and in patients with preexisting eye problems. Often people with kidney disease should take a reduced dosage. Clonidine should not be used by pregnant women, except in the rare case where the benefits of taking clonidine outweigh the risks to the developing fetus.
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Clonidine's effect on reducing circulating epinephrine by a central mechanism was used in the past as an investigatory test for pheochromocytomae, which are catecholamine-synthesizing tumors, usually of the adrenal medulla. In a Clonidine suppression test plasma catecholamines levels are measured before and 3 hours after a 0.3 µg/kg oral test dose has been given to a patient. A positive test occurs if there is no decrease in plasma levels.
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Clonidine should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. Use is limited to patients old enough to tolerate placement and management of an epidural catheter.
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GENERAL In patients who have developed localized contact sensitization to Clonidine-TTS (patch), substitution of oral clonidine hydrochloride therapy may be associated with the development of a generalized skin rash. In patients who develop an allergic reaction from Clonidine-TTS that extends beyond the local patch site (such as generalized skin rash, urticaria, or angioedema), oral clonidine hydrochloride substitution may elicit a similar reaction.
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