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Clonazepam: Treatment
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Seizure Disorders: The most frequently occurring side effects of Clonazepam are referable to CNS depression. Experience in treatment of seizures has shown that drowsiness has occurred in approximately 50% of patients and ataxia in approximately 30%. In some cases, these may diminish with time; behavior problems have been noted in approximately 25% of patients. Others, listed by system, are:
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Clonazepam is a 'calmer' and is often prescribed to treat (but not to cure) general symptoms of anxiety as well as panic disorder, with or without agoraphobia. Clonazepam is ... prescribed for the treatment of epilepsy and other seizure disorders.
Clonazepam is rarely used as a treatment for insomnia due to its relatively weak hypnotic effects. It has not been marketed for the treatment of insomnia mainly because its long half life makes it unsuitable for this application.
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Treatment-Emergent Depressive Symptoms: In the pool of two short-term placebo controlled trials, adverse events classified under the preferred term “depression” were reported in 7% of Clonazepam-treated patients compared to 1% of placebo-treated patients, without any clear pattern of dose relatedness. In these same trials, adverse events classified under the preferred term “depression” were reported as leading to discontinuation in 4% of Clonazepam-treated patients compared to 1% of placebo-treated patients. While these findings are noteworthy, Hamilton Depression Rating Scale (HAM-D) data collected in these trials revealed a larger decline in HAM-D scores in the Clonazepam group than the placebo group suggesting that Clonazepam-treated patients were not experiencing a worsening or emergence of clinical depression.
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