LYCOS RETRIEVER 
Clindamycin
built 613 days ago
Clindamycin is a semisynthetic antibiotic derived from lincomycin by 7 s ; - chloro -substitution of the 7 r ; - hydroxyl group of the lincomycin. 471. An observational study of changes to long-term medication after admission to an intensive care unit - Campbell A.J., Bloomfield R. and Noble D.W. [D.W. Noble, Intensive Care Unit, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, United Kingdom] - ANAESTHESIA 2006 61 11 ; - summ in ENGL Many patients admitted to intensive care units consume long-term medication. New drugs may be commenced during intensive care intended for the short term or longer.
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Clindamycin is an antibiotic of the lincosamides class and possesses similar properties to its sister compound lincomycin. To understand how the lincosamides work, it is important to understand how proteins are made by cells. The blueprint for any protein structure comes from the cell’s DNA. The relevant area of DNA (which is double stranded) opens and is transcribed to form a strand of messenger RNA. The messenger RNA travels from the cell nucleus outward to where a group of cell organs called ribosomes can become attached. The ribosomes grab the strand of messenger RNA and link the appropriate amino acids (bound to the transfer RNA) into the desired protein.
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Clindamycin and benzoyl peroxide have activity against Propionibacterium acnesin vitro. This organism has been associated with acne vulgaris. Benzoyl peroxide releases free-radical oxygen which oxidizes bacterial proteins in the sebaceous follicles decreasing the number of anaerobic bacteria and decreasing irritating-type free fatty acids. Clindamycin reversibly binds to 50S ribosomal subunits preventing peptide bond formation ... inhibiting bacterial protein synthesis; bacteriostatic or bactericidal depending on drug concentration, infection site, and organism.
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Clindamycin has a bacteriostatic effect. Clindamycin interferes with bacterial protein synthesis, in a similar way as erythromycin and chloramphenicol, by binding to the 50S subunit of the bacterial ribosome. This causes antagonism if administered simultaneously and possible cross-resistance.
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Concentrations of Clindamycin in the serum increased linearly with increased dose. Serum levels exceed the MIC (minimum inhibitory concentration) for most indicated organisms for at least six hours following administration of the usually recommended doses. Clindamycin is widely distributed in body fluids and tissues (including bones). The average biological half-life is 2.4 hours. Approximately 10% of the bioactivity is excreted in the urine and 3.6% in the feces; the remainder is excreted as bioinactive metabolites.
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To use the cream: Clindamycin vaginal cream is only for use in the vagina. Place in the vagina using the special applicator supplied with the cream. Wash hands before and after use. Fill the applicator with cream. Lie on your back, part and bend your knees. Insert the applicator into the vagina and push the plunger to expel the cream into the vagina.
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Clindamycin